The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
May. 10, 2016

Filed:

Feb. 16, 2011
Applicants:

Howard Bregman, Melrose, MA (US);

John L. Buchanan, Newton, MA (US);

Nagasree Chakka, Lexington, MA (US);

Erin F. Dimauro, Cambridge, MA (US);

Bingfan Du, Cambridge, MA (US);

Hanh Nho Nguyen, Arlington, MA (US);

Xiao Mei Zheng, Natick, MA (US);

Inventors:

Howard Bregman, Melrose, MA (US);

John L. Buchanan, Newton, MA (US);

Nagasree Chakka, Lexington, MA (US);

Erin F. Dimauro, Cambridge, MA (US);

Bingfan Du, Cambridge, MA (US);

Hanh Nho Nguyen, Arlington, MA (US);

Xiao Mei Zheng, Natick, MA (US);

Assignee:

AMGEN INC., Thousand Oaks, CA (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 471/10 (2006.01); C07D 401/04 (2006.01); C07D 403/04 (2006.01); C07D 251/48 (2006.01); C07D 213/74 (2006.01); C07D 239/48 (2006.01);
U.S. Cl.
CPC ...
C07D 471/10 (2013.01); C07D 213/74 (2013.01); C07D 239/48 (2013.01); C07D 251/48 (2013.01); C07D 401/04 (2013.01); C07D 403/04 (2013.01);
Abstract

The present invention provides compounds that are inhibitors of voltage-gated sodium channels (Nav), in particular Nav 1.7, and are therefore useful for the treatment of diseases treatable by inhibition of these channels, in particular, chronic pain disorders. Also provided are pharmaceutical compositions containing such compounds and processes for preparing such compounds.


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