The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 10, 2016
Filed:
Dec. 18, 2009
M. Amin Khan, Morgan Hill, CA (US);
Paul L. Wood, Harrogate, TN (US);
Dayan Goodenowe, Saskatoon, CA;
Rishikesh Mankidy, Saskatoon, CA;
Pearson Ahiahonu, Saskatoon, CA;
M. Amin Khan, Morgan Hill, CA (US);
Paul L. Wood, Harrogate, TN (US);
Dayan Goodenowe, Saskatoon, CA;
Rishikesh Mankidy, Saskatoon, CA;
Pearson Ahiahonu, Saskatoon, CA;
Phenomenome Discoveries Inc., Saskatoon, Saskatchewan, CA;
Abstract
Described herein are routes of synthesis and therapeutic uses of 1-alkyl, 2-acyl glycerol derivatives of formula I: which when administered to mammalian biological systems result in increased cellular concentrations of specific sn-2 substituted ethanolamine plasmalogens independent of the ether lipid synthesis capacity of the system. Elevating levels of the specific sn-2 substituted species in this way can cause lowering of membrane cholesterol levels and the lowering of amyloid secretion. These compounds can be used for the treatment or prevention of diseases of aging associated with increased membrane cholesterol, increased amyloid, and decreased plasmalogen levels, such as neurodegeneration (including Alzheimer's disease, Parkinson's disease and age-related macular degeneration), cognitive impairment, dementia, cancer (e.g. prostate, lung, breast, ovarian, and kidney cancers), osteoporosis, bipolar disorder and vascular diseases (such as atherosclerosis, hypercholesterolemia).