The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 10, 2016
Filed:
Dec. 22, 2011
Thorsten Steinberg, Mannheim, DE;
Karen Lienkamp, Freiburg, DE;
Pascal Tomakidi, Freiburg, DE;
Ali Al-ahmad, Freiburg, DE;
Thorsten Steinberg, Mannheim, DE;
Karen Lienkamp, Freiburg, DE;
Pascal Tomakidi, Freiburg, DE;
Ali Al-Ahmad, Freiburg, DE;
UNIVERSITAETSKLINIKUM FREIBURG, Freiburg, DE;
ALBERT-LUDWIGS-UNIVERSITAET FREIBURG, Freiburg, DE;
Abstract
The present invention relates to substrates comprising covalently attached antimicrobial polymers, which act as synthetic mimics of antimicrobial peptides (SMAMPs) and are preferably obtained by ring opening metathesis polymerization (ROMP). The inventive antimicrobial polymers exhibit a molecular weight of more than 100,000 g moland are preferably covalently attached to the surface of a substrate, e.g. an implant, a medical device, medical equipment or a (tissue-supporting) biomaterial, etc. Covalent bonding may be carried out using a photoreactive crosslinker but also by 'grafting onto' or 'grafting from'. The present invention is also directed to uses of the inventive antimicrobial polymers as defined herein, e.g. for antimicrobially coating a surface of such a substrate with a layer of the inventive antimicrobial polymer.