The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 03, 2016
Filed:
Dec. 29, 2013
Applicants:
Jian Chen, Wuxi, CN;
Jingwen Zhou, Wuxi, CN;
Hongwei Guo, Wuxi, CN;
Guocheng Du, Wuxi, CN;
Inventors:
Assignee:
Jiangnan University, Wuxi, JS, CN;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 15/74 (2006.01); C12N 1/20 (2006.01); C12P 7/50 (2006.01); C07K 14/39 (2006.01); C12N 15/81 (2006.01); C12N 1/16 (2006.01);
U.S. Cl.
CPC ...
C12P 7/50 (2013.01); C07K 14/39 (2013.01); C12N 1/16 (2013.01); C12N 15/815 (2013.01);
Abstract
The present invention provides four keto acid transporter encoding sequences selected from 6611 protein coding sequences ofCLIB122 database. Also provided are recombinantstrains overexpressing the keto acid transporters, which have increased extracellular secretion of α-ketoglutarate. The present invention can be used to increase extracellular levels of α-ketoglutarate during the fermentation process and lower downstream purification cost for α-ketoglutarate production.