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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9327027 B1

PDFFull Text
Date of Patent:
May. 03, 2016

Filed:

Jul. 28, 2011

Intrinsically magnetic hydroxyapatite

Applicants:

Anna Tampieri, Faenza, IT;

Elena Landi, Dozza, IT;

Monica Sandri, Cavriago, IT;

Daniele Pressato, Montegrotto Terme, IT;

José Rivas Rey, Ames, ES;

Manuel Banobre López, Vilarmaior, ES;

Maurilio Marcacci, Bologna, IT;

Inventors:

Anna Tampieri, Faenza, IT;

Elena Landi, Dozza, IT;

Monica Sandri, Cavriago, IT;

Daniele Pressato, Montegrotto Terme, IT;

José Rivas Rey, Ames, ES;

Manuel Banobre López, Vilarmaior, ES;

Maurilio Marcacci, Bologna, IT;

Assignees:

CONSIGLIO NAZIONALE DELLE RICERCHE, Rome, IT;

UNIVERSIDADE DE SANTIAGO DE COMPOSTELA, Santiago, ES;

FIN-CERAMICA FAENZA S.P.A., Faenza, IT;

Attorneys:

Silvia Salvadori, P.C.

Silvia Salvadori

Primary Examiner:

Bethany Barham

Assistant Examiner:

Dominic Lazaro

Int. Cl.
CPC ...
A61K 47/02 (2006.01); A61K 49/08 (2006.01); A61L 27/12 (2006.01); A61K 49/00 (2006.01); A61L 27/54 (2006.01); C01B 25/32 (2006.01); C01B 25/45 (2006.01);
U.S. Cl.
CPC ...
A61K 47/02 (2013.01); A61K 49/0002 (2013.01); A61K 49/08 (2013.01); A61L 27/12 (2013.01); A61L 27/54 (2013.01); C01B 25/32 (2013.01); C01B 25/322 (2013.01); C01B 25/45 (2013.01); A61L 2300/414 (2013.01); A61L 2300/64 (2013.01); A61L 2400/12 (2013.01); A61L 2430/02 (2013.01); A61L 2430/06 (2013.01); C01P 2004/62 (2013.01); C01P 2006/62 (2013.01); C01P 2006/64 (2013.01);
Abstract

The present invention relates to hydroxyapatite doped with Feions and Feions which partially substitute the calcium ions in the crystal lattice. The hydroxyapatite is characterized by an intrinsic magnetism of 0.05 to 8 emu/g, measured by applying a magnetic field of 34 Oe, due to the presence of magnetic nano-domains in the crystal lattice of HA, given the limited amount of magnetic secondary phases present, less than about 3% by volume. The intrinsically magnetic hydroxyapatite can be loaded with biological substances selected in the group consisting of proteins, genes, stem cells, growth factors, vascularization factors, active substances and drugs, under the control of an external magnetic field, as a carrier and release agent for biological substances or drugs, as a contrast agent in diagnostics or for bone or osteocartilage regeneration.

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