The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
May. 03, 2016

Filed:

Nov. 09, 2012
Applicant:

The Penn State Research Foundation, University Park, PA (US);

Inventors:

Mark Kester, Harrisburg, PA (US);

Thomas Stover, Hershey, PA (US);

Tao Lowe, Hershey, PA (US);

James H. Adair, State College, PA (US);

Young Shin Kim, Hershey, PA (US);

Assignee:

The Penn State Research Foundation, University Park, PA (US);

Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 31/164 (2006.01); A61K 47/02 (2006.01); A61K 9/50 (2006.01); A61K 9/51 (2006.01); A61K 47/48 (2006.01); A61K 9/127 (2006.01); A61K 48/00 (2006.01); B82Y 5/00 (2011.01);
U.S. Cl.
CPC ...
A61K 31/164 (2013.01); A61K 9/1271 (2013.01); A61K 9/1272 (2013.01); A61K 9/501 (2013.01); A61K 9/51 (2013.01); A61K 9/5115 (2013.01); A61K 47/02 (2013.01); A61K 47/482 (2013.01); A61K 47/48215 (2013.01); A61K 47/48315 (2013.01); A61K 48/00 (2013.01); B82Y 5/00 (2013.01); Y10S 977/783 (2013.01); Y10S 977/907 (2013.01);
Abstract

A system and method for optimizing the systemic delivery of growth-arresting lipid-derived bioactive drugs or gene therapy agents to an animal or human in need of such agents utilizing nanoscale assembly systems, such as liposomes, resorbable and non-aggregating nanoparticle dispersions, metal or semiconductor nanoparticles, or polymeric materials such as dendrimers or hydrogels, each of which exhibit improved lipid solubility, cell permeability, an increased circulation half life and pharmacokinetic profile with improved tumor or vascular targeting.


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