The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 26, 2016
Filed:
Sep. 07, 2012
Applicants:
Takahiro Ochiya, Tokyo, JP;
Tomohiro Fujiwara, Tokyo, JP;
Inventors:
Takahiro Ochiya, Tokyo, JP;
Tomohiro Fujiwara, Tokyo, JP;
Assignees:
3-D Matrix Ltd., Tokyo, JP;
National Cancer Center, Tokyo, JP;
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 48/00 (2006.01); C12N 15/113 (2010.01); C12Q 1/68 (2006.01); G01N 33/50 (2006.01);
U.S. Cl.
CPC ...
C12N 15/113 (2013.01); C12Q 1/6886 (2013.01); G01N 33/5011 (2013.01); C12N 2310/113 (2013.01); C12N 2310/141 (2013.01); C12N 2310/3231 (2013.01); C12N 2320/11 (2013.01);
Abstract
Provided are methods and compositions useful in the diagnosis, treatment, and monitoring of osteosarcoma. Antisense to certain microRNA (miRNA) found to be associated with cancer stem cells (CSCs) or tumor-initiating cells (TICs) of osteosarcoma are useful to suppress tumor growth and metastasis, and prolong survival. Antisense oligonucleotides to miR-133a are synergistic in combination with standard chemotherapy such as cisplatin in the treatment of osteosarcoma.