The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 26, 2016
Filed:
Jun. 17, 2011
Applicants:
Clark T. Hung, Ardsley, NY (US);
Grace D. O'connell, Lansdowne, PA (US);
Inventors:
Clark T. Hung, Ardsley, NY (US);
Grace D. O'Connell, Lansdowne, PA (US);
Assignee:
The Trustees of Columbia University in the City of New York, New York, NY (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 5/00 (2006.01); C12N 5/077 (2010.01); A61K 35/32 (2015.01);
U.S. Cl.
CPC ...
C12N 5/0655 (2013.01); A61K 35/32 (2013.01); C12N 2500/46 (2013.01); C12N 2500/60 (2013.01); C12N 2501/115 (2013.01); C12N 2501/135 (2013.01); C12N 2501/15 (2013.01); C12N 2501/73 (2013.01); C12N 2533/76 (2013.01);
Abstract
The present disclosure provides cell culture medium comprising trimethylamine N-oxide (TMAO). Progenitor cells cultured with such medium can form connective tissue with enhanced mechanical properties. Also provided are methods of forming connective tissue and methods of treatment for connective tissue defects.