The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Apr. 26, 2016

Filed:

Dec. 05, 2013
Applicants:

Leidos, Inc., Reston, VA (US);

The United States of America, As Represented BY the Secretary, Dept. of Health and Human Services, Bethesda, MD (US);

Inventors:

Gabriel M. Gutierrez, Reston, VA (US);

James Pannucci, Reston, VA (US);

Amy Noe, Reston, VA (US);

Steve Chienwen Huang, Reston, VA (US);

Scott Winram, Reston, VA (US);

Annie Xiaoyan Mo, Bethesda, MD (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 39/015 (2006.01); A61K 45/00 (2006.01); A61K 39/395 (2006.01); C07K 16/20 (2006.01); A61K 45/06 (2006.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
C07K 16/205 (2013.01); A61K 39/015 (2013.01); A61K 39/39575 (2013.01); A61K 45/06 (2013.01); A61K 2039/505 (2013.01); C07K 2317/24 (2013.01); C07K 2317/33 (2013.01); C07K 2317/34 (2013.01); C07K 2317/565 (2013.01); C07K 2317/622 (2013.01); C07K 2317/76 (2013.01);
Abstract

This disclosure provides antibodies that are useful for preventing and/or treating malaria. The epitope to which the antibodies bind is in close proximity to the conserved proteolytic cleavage site ofcircumsporozoite protein (CSP), and the antibodies provided in this disclosure can prevent cleavage and inhibitsporozoites from invading the liver.


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