The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 26, 2016
Filed:
Jun. 12, 2007
Kang Choon Lee, Seoul, KR;
Su Young Chae, Gwangju, KR;
Yu Seok Youn, Seoul, KR;
Won Bae Kim, Seoul, KR;
Sung Kwon Lee, Seoul, KR;
Kang Choon Lee, Seoul, KR;
Su Young Chae, Gwangju, KR;
Yu Seok Youn, Seoul, KR;
Won Bae Kim, Seoul, KR;
Sung Kwon Lee, Seoul, KR;
Theraly Pharmaceuticals Inc., Elkridge, MD (US);
Abstract
Disclosed herein are an N-terminal modified PEG-TRAIL conjugate and a preparation method and use thereof. The PEG-TAIL conjugate has pharmaceutical activity identical or similar to that of native TRAIL (TNF-related apoptosis-inducing ligand) with extended in vivo half-life and enhanced stability. Compared to native TRAIL, the PEG-TAIL conjugate exhibits high solubility and solution stability, with highly improved pharmacokinetic profiles. Thus, the PEG-TAIL conjugate may be very useful for preventing and treating proliferative diseases and autoimmune diseases.