The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 26, 2016
Filed:
Feb. 20, 2012
Pierfausto Seneci, Desenzano del Garda, IT;
Laura Belvisi, Villasanta, IT;
Federica Cossu, Milan, IT;
Domenico Delia, Milan, IT;
Carmelo Drago, Scordia, IT;
Daniele Lecis, Arese, IT;
Stefano Maiorana, Milan, IT;
Leonardo Pierpaolo Manzoni, Lissone, IT;
Eloise Mastrangelo, Milan, IT;
Mario Milani DE Mayo DE Mari, Milan, IT;
Paola Maria Chiara Perego, Monza, IT;
Francesca Vasile, Milan, IT;
Pierfausto Seneci, Desenzano del Garda, IT;
Laura Belvisi, Villasanta, IT;
Federica Cossu, Milan, IT;
Domenico Delia, Milan, IT;
Carmelo Drago, Scordia, IT;
Daniele Lecis, Arese, IT;
Stefano Maiorana, Milan, IT;
Leonardo Pierpaolo Manzoni, Lissone, IT;
Eloise Mastrangelo, Milan, IT;
Mario Milani de Mayo de Mari, Milan, IT;
Paola Maria Chiara Perego, Monza, IT;
Francesca Vasile, Milan, IT;
BioNTech AG, Mainz, DE;
Abstract
The present invention relates to conformationally constrained homo- and heterodimeric mimetics of Smac with function as inhibitors of Inhibitor of Apoptosis Proteins (IAPs), the invention also relates to the use of these compounds in therapy, wherein the induction of apoptotic cell death is beneficial, especially in the treatment of cancer, alone or in combination with other active ingredients.