The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 26, 2016
Filed:
Oct. 05, 2011
Applicant:
Christopher Mcguigan, Cardiff, GB;
Inventor:
Christopher McGuigan, Cardiff, GB;
Assignee:
NuCana BioMed Limited, Camberley, GB;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A01N 43/04 (2006.01); A61K 31/70 (2006.01); C07H 19/04 (2006.01); C07H 19/12 (2006.01); C07H 19/10 (2006.01);
U.S. Cl.
CPC ...
C07H 19/10 (2013.01);
Abstract
Phosphorodiamidate derivatives of e.g. gemcitabine are provided for use in treating cancer. In one embodiment, the two amidate motifs each comprises NR'R″ where R′ is H and R″ is CRRCOR, where Ris H, Ris the side chain, including H and C, of a naturally occurring alpha amino acid, and Ris branched or unbranched, substituted or unsubstituted, acyclic or cyclic alkyl, including t-butyl-CH2-, benzyl and Cto Ccycloalkyl. Formula (I).