Pyrrolobenzodiazepines

Abstract

A compound of formula (I) or a salt or solvate thereof, wherein the dotted double bond indicates the presence of a single or double bond between C2 and C3; Ris selected from —H, —OH, ═O, ═CH, —CN, —R, OR, halo, dihalo, ═CHR, ═CHRR', —O—SO—R, COR and COR; Ris selected from H, R, OH, OR, SH, SR, NH, NHR, NRR′, nitro, MeSn and halo; where R and R′ are independently selected from optionally substituted Calkyl, Cheterocyclyl and Caryl groups; Rand Reither together form a double bond, or are selected from H and QRrespectively, where Q is selected from O, S and NH and Ris H or Calkyl or H and SOM, where x is 2 or 3, and M is a monovalent pharmaceutically acceptable cation; A is selected from (A1), (A2), (A3), (A4) or (A5) where Xand Yare selected from: CH and NH; CH and NMe; N and NMe; CH and S; N and S; N and O; and CH and O, respectively; Xand Yare selected from: CH and NH; CH and NMe; N and NMe; CH and S; N and S; N and O; and CH and O, respectively; Zis selected from O and S; Zis selected from CH and N; F is selected from a single bond and -(E-F)—; each E is independently selected from a single bond, and —C(═O)—NH—; each Fis independently a Cheteroarylene group; m is 1, 2 or 3; G is selected from hydrogen, Calkyl, —C(═O)—O—Calkyl, —(CH)—Cheterocycloalkyl, and —O—(CH)—Cheterocycloalkyl group; each n is 0-4; provided that A2 is not A2′, where Xand Yof A2′ are selected from: CH and NMe; COH and NMe; CH and S; N and NMe; N and S, respectively; and provided that A3 is not A3′, where Xand Yof A3′ are selected from: CH and NMe; COH and NMe; CH and S; N and NMe; N and S, respectively; B is either a single bond or (B1), where X and Y of B1 are selected from: CH and NMe; COH and NMe; CH and S; N and NMe; N and S, respectively; and Ris Calkyl.