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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9321761 B1

PDFFull Text
Date of Patent:
Apr. 26, 2016

Filed:

Dec. 18, 2014

Pyridyl inhibitors of hedgehog signalling

Applicants:

Genentech, Inc., South San Francisco, CA (US);

Curis, Inc., Lexington, MA (US);

Inventors:

Janet L. Gunzner-Toste, Piedmont, CA (US);

Daniel Sutherlin, Burlingame, CA (US);

Mark S. Stanley, Pacifica, CA (US);

Liang Bao, Freemont, CA (US);

Georgette M. Castanedo, Redwood City, CA (US);

Rebecca L. LaLonde, Portland, OR (US);

Shumei Wang, Foster City, CA (US);

Mark E. Reynolds, Millbrae, CA (US);

Scott J. Savage, Burlingame, CA (US);

Kimberly Malesky, Boston, MA (US);

Michael S. Dina, Daly City, CA (US);

Michael F. T. Koehler, Palo Alto, CA (US);

Assignees:

CURIS, INC., Lexington, MA (US);

GENENTECH, INC., South San Francisco, CA (US);

Attorney:

Millen White Zelano & Branigan, PC

Primary Examiner:

Zinna Northington Davis

Int. Cl.
CPC ...
C07D 413/12 (2006.01); C07D 417/04 (2006.01); C07D 417/12 (2006.01); C07D 213/38 (2006.01); C07D 213/40 (2006.01); C07D 213/56 (2006.01); C07D 213/70 (2006.01); C07D 213/75 (2006.01); C07D 213/81 (2006.01); C07D 213/82 (2006.01); C07D 401/12 (2006.01); C07D 401/14 (2006.01); C07D 405/12 (2006.01); C07D 409/12 (2006.01); C07F 9/58 (2006.01);
U.S. Cl.
CPC ...
C07D 417/12 (2013.01); C07D 213/38 (2013.01); C07D 213/40 (2013.01); C07D 213/56 (2013.01); C07D 213/70 (2013.01); C07D 213/75 (2013.01); C07D 213/81 (2013.01); C07D 213/82 (2013.01); C07D 401/12 (2013.01); C07D 401/14 (2013.01); C07D 405/12 (2013.01); C07D 409/12 (2013.01); C07D 413/12 (2013.01); C07D 417/04 (2013.01); C07F 9/588 (2013.01);
Abstract

The invention provides novel inhibitors of hedgehog signaling that are useful as a therapeutic agents for treating malignancies where the compounds have the general formula I: wherein A, X, Y R, R, R, R, m and n are as described herein.

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