The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Apr. 26, 2016

Filed:

May. 20, 2013
Applicants:

The Regents of the University of California, Oakland, CA (US);

Universita Degli Studi Di Urbino “carlo Bo”, Urbino, IT;

Universita Degli Studi Di Parma, Parma, IT;

Inventors:

Daniele Piomelli, Irvine, CA (US);

Giorgio Tarzia, Petriano, IT;

Marco Mor, Ghedi, IT;

Andrea Duranti, Urbino, IT;

Andrea Tontini, Pesaro, IT;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 305/10 (2006.01); A61K 31/165 (2006.01); A61K 31/195 (2006.01); A61K 31/337 (2006.01); A61K 31/365 (2006.01);
U.S. Cl.
CPC ...
C07D 305/10 (2013.01); A61K 31/165 (2013.01); A61K 31/195 (2013.01); A61K 31/337 (2013.01); A61K 31/365 (2013.01);
Abstract

Compounds and pharmaceutical compositions are contemplated that inhibit N-acyl-ethanolamine-hydrolyzing acid amidase (NAAA) to so increase the concentration of the substrate of NAAA, palmitoylethanolamide (PEA). NAAA inhibition is contemplated to be effective to alleviate conditions associated with a reduced concentration of PEA. Among other uses, various NAAA inhibitors are especially contemplated as therapeutic agents in the treatment of inflammatory diseases.


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