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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9320807 B1

PDFFull Text
Date of Patent:
Apr. 26, 2016

Filed:

Feb. 12, 2014

Drug delivery of temozolomide for systemic based treatment of cancer

Applicant:

Cedars-sinai Medical Center, Los Angeles, CA (US);

Inventors:

Rameshwar Patil, Los Angeles, CA (US);

Eggehard Holler, Los Angeles, CA (US);

Keith L. Black, Los Angeles, CA (US);

Julia Y. Ljubimova, Studio City, CA (US);

Assignee:

CEDARS-SINAI MEDICAL CENTER, Los Angeles, CA (US);

Attorney:

Volpe and Koenig, P.C.

Primary Examiner:

Robert A Wax

Assistant Examiner:

Randeep Singh

Int. Cl.
CPC ...
A61K 38/00 (2006.01); A61K 31/74 (2006.01); A61K 47/48 (2006.01); C08G 63/48 (2006.01); C08G 63/91 (2006.01); C08L 89/00 (2006.01); C08F 283/00 (2006.01); C08G 69/48 (2006.01); C08L 67/00 (2006.01); C08L 77/00 (2006.01); A61K 31/425 (2006.01);
U.S. Cl.
CPC ...
A61K 47/482 (2013.01); A61K 31/425 (2013.01); A61K 47/48061 (2013.01); A61K 47/48338 (2013.01); A61K 47/48384 (2013.01); A61K 47/48561 (2013.01); A61K 47/48692 (2013.01);
Abstract

The present invention relates to methods of drug delivery for the treatment of a condition or disease, such as cancer. In one embodiment, the invention provides a method of preparing a multifunctional nanoconjugate of temozolomide (TMZ) by conjugating TMZ in its hydrazide form to a polymalic acid platform. In another embodiment, the polymalic acid platform is conjugated to a monoclonal antibody to transferrin receptor, a trileucine (LLL) moiety, and/or a polyethylene glycol (PEG) moiety. The present invention relates to methods of drug delivery for the treatment of a condition or disease, such as cancer. In one embodiment, the invention provides a method of preparing a multifunctional nanoconjugate of temozolomide (TMZ) by conjugating TMZ in its hydrazide form to a polymalic acid platform. In another embodiment, the polymalic acid platform is conjugated to a monoclonal antibody to transferrin receptor, a trileucine (LLL) moiety, and/or a polyethylene glycol (PEG) moiety.

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