The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 26, 2016
Filed:
Jun. 04, 2010
Jennifer Gamble, Double Bay, AU;
Mathew Vadas, Double Bay, AU;
Gregory Goodall, Netherby, AU;
Jennifer Young, Petersham, AU;
Jennifer Gamble, Double Bay, AU;
Mathew Vadas, Double Bay, AU;
Gregory Goodall, Netherby, AU;
Jennifer Young, Petersham, AU;
CENTENARY INSTITUTE OF CANCER MEDICINE AND CELL BIOLOGY, Camperdown, AU;
UNIVERSITY OF SYDNEY, Sydney, AU;
WENKART FOUNDATION, Leichardt, AU;
Abstract
The present invention relates to methods for modulating angiogenesis, comprising administering to a subject, or cells or tissue derived therefrom: (i) one or more miRNA, or precursors or variants thereof, wherein at least one of said miRNA comprises a seed region comprising the sequence UCACAGU (SEQ ID NO:37) to inhibit angiogenesis; or (ii) one or more antagonists of a miRNA, wherein said miRNA comprises a seed region comprising the sequence UCACAGU (SEQ ID NO:37) to promote or induce angiogenesis. Also provided are methods of diagnosis of conditions associated with abnormal angiogenesis, or determining predisposition thereto. Suitable pharmaceutical compositions are also provided.