The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 26, 2016
Filed:
Jan. 30, 2015
Applicant:
Institute for Cancer Research, Philadelphia, PA (US);
Inventors:
Alexander Kutikov, Voorhees, NJ (US);
Vladimir Kolenko, Philadelphia, PA (US);
Seth M. Cohen, San Marcos, CA (US);
Robert G. Uzzo, Ambler, PA (US);
Ervin Teper, Huntington Valley, PA (US);
Assignee:
Other;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/47 (2006.01); A61K 38/19 (2006.01); A61K 45/06 (2006.01); A61K 31/4709 (2006.01);
U.S. Cl.
CPC ...
A61K 31/47 (2013.01); A61K 31/4709 (2013.01); A61K 38/191 (2013.01); A61K 45/06 (2013.01);
Abstract
The invention provides zinc chelating agents and formulations thereof that deplete XIAP in cancer cells and sensitize the cells to apoptosis-inducing agents. The invention provides methods for sensitizing apoptosis-resistant cancer cells to apoptosis-inducing agents, as well as methods for treating a subject with a combined therapy of a zinc chelating agent and an apoptosis-inducing agent.