The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Apr. 26, 2016

Filed:

Aug. 30, 2013
Applicant:

Taisho Pharmaceutical Co., Ltd, Tokyo, JP;

Inventors:

Naoki Kojima, Tokyo, JP;

Richard J. Roman, Brandon, MS (US);

Noriyuki Miyata, Tokyo, JP;

Teisuke Takahashi, Tokyo, JP;

Hideki Tomoike, Tokyo, JP;

Takuya Takeda, Tokyo, JP;

Assignee:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/382 (2006.01); A61K 31/40 (2006.01); A61K 31/41 (2006.01); A61K 31/401 (2006.01); A61K 45/06 (2006.01);
U.S. Cl.
CPC ...
A61K 31/382 (2013.01); A61K 31/40 (2013.01); A61K 31/401 (2013.01); A61K 31/41 (2013.01); A61K 45/06 (2013.01);
Abstract

Medicaments that depend on a combination of SGLT 2 inhibitors and antihypertensive drugs and which are useful in the treatment of diseases involving at least hypertension or diabetes mellitus as a risk factor of cardiovascular events, as well as methods of treating the diseases are provided. Since the present invention exhibits a superior hypotensive action that cannot be attained by any single antihypertensive drugs, the conventional problems associated with the use of two or more antihypertensive drugs in order to lower the blood pressure to the desired level can be solved. In addition, the present invention shows a marked therapeutic efficacy in diabetes mellitus, a disease associated with diabetes mellitus, or complications of diabetes mellitus, in particular, diabetic nephropathy. As a further advantage, the present invention is also useful for the treatment of diseases involving lowered renal function.


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