The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Apr. 26, 2016

Filed:

May. 10, 2012
Applicants:

Basil M. Hantash, East Palo Alto, CA (US);

Anan Abu Ubeid, San Jose, CA (US);

Inventors:

Basil M. Hantash, East Palo Alto, CA (US);

Anan Abu Ubeid, San Jose, CA (US);

Assignee:

Escape Therapeutics, Inc., San Jose, CA (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 8/64 (2006.01); C07K 7/06 (2006.01); C12N 9/02 (2006.01); A61Q 19/02 (2006.01); A61K 8/14 (2006.01); C07K 5/11 (2006.01); A61Q 19/00 (2006.01); A61K 38/00 (2006.01);
U.S. Cl.
CPC ...
A61K 8/64 (2013.01); A61K 8/14 (2013.01); A61Q 19/007 (2013.01); A61Q 19/02 (2013.01); C07K 5/1019 (2013.01); C07K 7/06 (2013.01); C12N 9/0071 (2013.01); C12Y 114/18001 (2013.01); A61K 38/00 (2013.01); A61K 2800/30 (2013.01); A61K 2800/782 (2013.01); A61K 2800/81 (2013.01); A61K 2800/82 (2013.01);
Abstract

Disclosed are peptides that inhibit the enzymatic activity of tyrosinase, as well as formulations and methods for their use in the reduction of skin pigmentation, and methods of administering the inhibitory pep tides in a topical formulation. Preferred octapeptide sequences are internally rich in tryptophan and/or tyrosine or arginine. The present invention is further directed to kits and compositions containing the present peptides, and methods of treatment of conditions involving expression of tyrosinase, in which the present peptides are administered topically for the treatment of conditions involving melanocyte activity in the skin.


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