The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 19, 2016
Filed:
Jan. 11, 2011
Leonid Gorelik, Quincy, MA (US);
Kenneth J. Simon, Cambridge, MA (US);
Meena Subramanyam, Stoneham, MA (US);
Mia Marie Rushe, Everett, MA (US);
Leonid Gorelik, Quincy, MA (US);
Kenneth J. Simon, Cambridge, MA (US);
Meena Subramanyam, Stoneham, MA (US);
Mia Marie Rushe, Everett, MA (US);
BIOGEN MA INC., Cambridge, MA (US);
Abstract
The disclosure relates to methods and reagents for analyzing samples for the presence of JC virus antibodies. Disclosed is a method that includes obtaining a biological sample from a subject (e.g., plasma, serum, blood, urine, or cerebrospinal fluid), contacting the sample with highly purified viral-like particles (HPVLPs) under conditions suitable for binding of a JCV antibody in the sample to an HPVLP, and detecting the level of JCV antibody binding in the sample to HPVLP. In one embodiment, determining the level of anti-JCV antibodies in the subject sample provides a method of identifying PML risk in a subject.