The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 19, 2016
Filed:
Mar. 17, 2010
Peter Richard, Espoo, FI;
Marilyn Wiebe, Espoo, FI;
Mervi Toivari, Espoo, FI;
Dominik Mojzita, Espoo, FI;
Laura Ruohonen, Espoo, FI;
Merja Penttilä, Espoo, FI;
Peter Richard, Espoo, FI;
Marilyn Wiebe, Espoo, FI;
Mervi Toivari, Espoo, FI;
Dominik Mojzita, Espoo, FI;
Laura Ruohonen, Espoo, FI;
Merja Penttilä, Espoo, FI;
Teknologian Tutkimuskeskus VTT, Espoo, FI;
Abstract
Provided is a method for producing xylonic acid from xylose with a recombinant fungal strain that is genetically modified to express a xylose dehydrogenase gene, which is able to convert xylose to xylonolactone, which is spontaneously or enzymatically hydrolyzed to xylonic acid. The xylonic acid is excreted outside the host cell. Xylonate production may be coupled with xylitol production. Alternatively, if xylitol production is not desired, its production is reduced by removing the aldose reductase (or specific xylose reductase) enzyme, which converts xylose to xylitol. Expression of a heterologous lactonase encoding gene may result in higher acid concentrations. The method is suitable for producing xylonic acid from a hemicellulose hydrolysate such as hydrolyzed lignocellulosic plant biomass.