The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 19, 2016
Filed:
Apr. 05, 2012
Philippe Duchateau, Gargan, FR;
Julien Valton, Paris, FR;
Claudia Bertonati, Paris, FR;
Jean-charles Epinat, Paris, FR;
George H. Silva, Trevise, FR;
Alexandre Juillerat, Paris, FR;
Marine Beurdeley, Paris, FR;
Philippe Duchateau, Gargan, FR;
Julien Valton, Paris, FR;
Claudia Bertonati, Paris, FR;
Jean-Charles Epinat, Paris, FR;
George H. Silva, Trevise, FR;
Alexandre Juillerat, Paris, FR;
Marine Beurdeley, Paris, FR;
CELLECTIS, S.A., Paris, FR;
Abstract
The present invention relates to a method for the generation of compact Transcription Activator-Like Effector Nucleases (TALENs) that can efficiently target and process double-stranded DNA. More specifically, the present invention concerns a method for the creation of TALENs that consist of a single TALE DNA binding domain fused to at least one catalytic domain such that the active entity is composed of a single polypeptide chain for simple and efficient vectorization and does not require dimerization to target a specific single double-stranded DNA target sequence of interest and process DNA nearby said DNA target sequence. The present invention also relates to compact TALENs, vectors, compositions and kits used to implement the method.