The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 19, 2016
Filed:
Dec. 23, 2010
Peter J. Hudson, Blackburn, AU;
Debra Tamvakis, Camberwell, AU;
Michael P. Wheatcroft, Southbank, AU;
Fabio Turatti, Docklands, AU;
Peter J. Hudson, Blackburn, AU;
Debra Tamvakis, Camberwell, AU;
Michael P. Wheatcroft, Southbank, AU;
Fabio Turatti, Docklands, AU;
A VIPEP PTY LIMITED, Parkville, Victoria, AU;
Abstract
The present invention provides an isolated protein comprising an immunoglobulin variable region comprising at least two cysteine residues positioned within framework region (FR) 2 and/or at least two cysteine residues positioned within framework region (FR3), wherein if at least two of the cysteine residues in FR2 and/or FR3 are not conjugated to a compound then an intra-framework disulphide bond is capable of forming between the cysteine residues. Preferably the protein comprises an immunoglobulin heavy chain variable region (V) and an immunoglobulin light chain variable region (V), wherein at least one of the variable regions comprises the two cysteine residues. The present invention also provides conjugates of the protein and another compound.