The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 19, 2016
Filed:
Nov. 14, 2011
Ziya Kaya, Heidelberg, DE;
Hugo Katus, Heidelberg, DE;
Oliver Zimmermann, Waltenhofen, DE;
Wolfgang Rottbauer, Ulm, DE;
Jan Torzewski, Immenstadt, DE;
Ziya Kaya, Heidelberg, DE;
Hugo Katus, Heidelberg, DE;
Oliver Zimmermann, Waltenhofen, DE;
Wolfgang Rottbauer, Ulm, DE;
Jan Torzewski, Immenstadt, DE;
RUPRECHT-KARLS-UNIVERSITÄT HEIDELBERG, Heidelberg, DE;
UNIVERSITÄT ULM, Ulm, DE;
Abstract
The present invention relates to the field of cell-based therapeutics. Specifically, the invention is concerned with a composition comprising a macrophage overexpressing interleukin 10 (IL-10) from transfected IL-10 encoding mRNA for use as a medicament. Moreover, a method for manufacturing a medicament for treating and/or preventing inflammation or a disease or disorder associated therewith comprising the steps of obtaining a macrophage from a sample of said subject, transfecting mRNA encoding IL-10 into said macrophage, and formulating said macrophage in a composition suitable for administration to the said subject, whereby the medicament is manufactured. Finally, a kit is provided for manufacturing such a medicament.