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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9315521 B1

PDFFull Text
Date of Patent:
Apr. 19, 2016

Filed:

Apr. 22, 2015

Pyrimidines as novel therapeutic agents

Applicant:

Université Laval, Quebec, CA;

Inventors:

Giorgio Attardo, Laval, CA;

Sasmita Tripathy, Pierre Fonds, CA;

Martin Gagnon, Montreal, CA;

Assignee:

Université Laval, Quebec, CA;

Attorney:

Clark & Elbing LLP

Primary Examiner:

Kristin Vajda

Int. Cl.
CPC ...
A61K 31/497 (2006.01); A61K 31/506 (2006.01); A61K 31/435 (2006.01); C07D 513/04 (2006.01); C07D 239/38 (2006.01); C07D 239/56 (2006.01); C07D 401/12 (2006.01); C07D 403/12 (2006.01); C07D 403/14 (2006.01); C07D 409/12 (2006.01); C07D 413/12 (2006.01); C07D 417/12 (2006.01); C07D 471/04 (2006.01); C07D 487/04 (2006.01); C07D 239/47 (2006.01); C07D 401/14 (2006.01);
U.S. Cl.
CPC ...
C07D 513/04 (2013.01); A61K 31/435 (2013.01); A61K 31/497 (2013.01); A61K 31/506 (2013.01); C07D 239/38 (2013.01); C07D 239/47 (2013.01); C07D 239/56 (2013.01); C07D 401/12 (2013.01); C07D 401/14 (2013.01); C07D 403/12 (2013.01); C07D 403/14 (2013.01); C07D 409/12 (2013.01); C07D 413/12 (2013.01); C07D 417/12 (2013.01); C07D 471/04 (2013.01); C07D 487/04 (2013.01);
Abstract

The present invention features compounds having the Formula (Ia) and (Ib) (e.g., a compound of any of Formulas ((Ia-2)-(Ia-21)), including other tautomers, stereoisomers, E/Z stereoisomers, prodrugs, pharmaceutically acceptable salts, and compositions thereof. The invention also features methods for treating or preventing pain (e.g., neuropathic pain), inflammation, or epilepsy in a patient by administering an effective amount of a compound of Formula (Ia) or (Ib). The invention also features a method for treating or preventing pain (e.g., neuropathic pain), inflammation, or epilepsy in a patient that includes administering to a patient in need thereof an effective amount of a compound of Formula (IIa) or (IIb) (e.g., a compound of any of Formulas ((IIa-2)-(IIa-6)). The compounds described herein (e.g., a compound of Formulas (Ia), (Ib), (IIa), or (IIb)) can also be used as anticonvulsants.

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