The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Apr. 19, 2016

Filed:

Sep. 09, 2013
Applicants:

Christian Beaulieu, Laval, CA;

David J. Bennett, New Hope, PA (US);

Christopher J. Bungard, Lansdale, PA (US);

Ronald K. Chang, Oreland, PA (US);

Sheldon Crane, Ile Perrot, CA;

Thomas J. Greshock, Collegeville, PA (US);

LI Hao, Singapore, SG;

Kate Holloway, Lansdale, PA (US);

Jesse J. Manikowski, Norristown, PA (US);

John A. Mccauley, Maple Glen, PA (US);

Daniel Mckay, Milton, MA (US);

Carmela Molinaro, West Point, PA (US);

Oscar Miguel Moradei, Kirkland, CA;

Philippe G. Nantermet, Lansdale, PA (US);

Christian Nadeau, Montreal, CA;

Satyanarayana Tummanapalli, Singapore, SG;

William Shipe, Chalfont, PA (US);

Sanjay Kumar Singh, Singapore, SG;

Vouy Linh Truong, Pierrefonds, CA;

Sivalenka Vijayasaradhi, Singapore, SG;

Peter D. Williams, Harleysville, PA (US);

Catherine M. Wiscount, Allentown, PA (US);

Inventors:

Christian Beaulieu, Laval, CA;

David J. Bennett, New Hope, PA (US);

Christopher J. Bungard, Lansdale, PA (US);

Ronald K. Chang, Oreland, PA (US);

Sheldon Crane, Ile Perrot, CA;

Thomas J. Greshock, Collegeville, PA (US);

Li Hao, Singapore, SG;

Kate Holloway, Lansdale, PA (US);

Jesse J. Manikowski, Norristown, PA (US);

John A. McCauley, Maple Glen, PA (US);

Daniel McKay, Milton, MA (US);

Carmela Molinaro, West Point, PA (US);

Oscar Miguel Moradei, Kirkland, CA;

Philippe G. Nantermet, Lansdale, PA (US);

Christian Nadeau, Montreal, CA;

Satyanarayana Tummanapalli, Singapore, SG;

William Shipe, Chalfont, PA (US);

Sanjay Kumar Singh, Singapore, SG;

Vouy Linh Truong, Pierrefonds, CA;

Sivalenka Vijayasaradhi, Singapore, SG;

Peter D. Williams, Harleysville, PA (US);

Catherine M. Wiscount, Allentown, PA (US);

Assignees:

MERCK SHARP & DOHME CORP., Rahway, NJ (US);

MERCK CANADA INC., Kirkland, Province of Quebec, CA;

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C07D 413/06 (2006.01); C07D 413/12 (2006.01); C07D 413/14 (2006.01); C07D 417/12 (2006.01); C07D 265/30 (2006.01); C07D 487/04 (2006.01); C07D 493/04 (2006.01); A61K 31/5375 (2006.01); A61K 31/5377 (2006.01); A61K 31/695 (2006.01); A61K 45/06 (2006.01); C07F 7/08 (2006.01);
U.S. Cl.
CPC ...
C07D 265/30 (2013.01); A61K 31/5375 (2013.01); A61K 31/5377 (2013.01); A61K 31/695 (2013.01); A61K 45/06 (2013.01); C07D 413/06 (2013.01); C07D 413/12 (2013.01); C07D 413/14 (2013.01); C07D 417/12 (2013.01); C07D 487/04 (2013.01); C07D 493/04 (2013.01); C07F 7/0814 (2013.01);
Abstract

The compounds encompassed by Formula I include compounds which are HIV protease inhibitors and other compounds which can be metabolized in vivo to HIV protease inhibitors. The compounds and their pharmaceutically acceptable salts are useful for the prophylaxis or treatment of infection by HIV and the prophylaxis, treatment, or delay in the onset of AIDS. The compounds and their salts can be employed as ingredients in pharmaceutical compositions, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines.


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