The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Apr. 19, 2016

Filed:

May. 17, 2013
Applicant:

Genentech, Inc., South San Francisco, CA (US);

Inventors:

Srinivasan Babu, South San Francisco, CA (US);

Francis Gosselin, South San Francisco, CA (US);

Yingqing Ran, South San Francisco, CA (US);

Travis Remarchuk, South San Francisco, CA (US);

Scott J. Savage, South San Francisco, CA (US);

Jeffrey Stults, South San Francisco, CA (US);

Herbert Yajima, South San Francisco, CA (US);

Assignee:

GENETECH, INC., South San Francisco, CA (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 239/70 (2006.01); C07D 403/04 (2006.01); C12P 17/16 (2006.01);
U.S. Cl.
CPC ...
C07D 239/70 (2013.01); C07D 403/04 (2013.01); C12P 17/165 (2013.01);
Abstract

The invention provides new processes for making and purifying salts of hydroxylated cyclopentapyrimidine compounds, which are useful as AKT inhibitors used in the treatment of diseases such as cancer, including the monohydrochloride salt of (S)-2-(4-chlorophenyl)-1-(4-((5R,7R)-7-hydroxy-5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)piperazin-1-yl)-3-(isopropylamino)propan-1-one.


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