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For the Inventor, By the Inventor

The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9315467 B1

PDFFull Text
Date of Patent:
Apr. 19, 2016

Filed:

Oct. 13, 2005

Compounds for nonsense suppression, and methods for their use

Applicants:

Neil Almstead, Princeton, NJ (US);

Gary M. Karp, Princeton Junction, NJ (US);

Richard Wilde, Somerville, NJ (US);

Ellen Welch, Califon, NJ (US);

Hongyu Ren, Dayton, NJ (US);

Inventors:

Neil Almstead, Princeton, NJ (US);

Gary M. Karp, Princeton Junction, NJ (US);

Richard Wilde, Somerville, NJ (US);

Ellen Welch, Califon, NJ (US);

Hongyu Ren, Dayton, NJ (US);

Assignee:

PTC Therapeutics, Inc., South Plainfield, NJ (US);

Attorney:

Hoffmann & Baron, LLP

Primary Examiner:

Craig Ricci

Int. Cl.
CPC ...
A61K 31/53 (2006.01); C07D 239/42 (2006.01); C07D 401/04 (2006.01); A61K 31/435 (2006.01); C07D 231/12 (2006.01); C07D 233/64 (2006.01); C07D 249/08 (2006.01); C07D 261/08 (2006.01); C07D 263/32 (2006.01); C07D 271/06 (2006.01); C07D 277/30 (2006.01); C07D 285/12 (2006.01); C07D 307/68 (2006.01); C07D 333/24 (2006.01); C07D 413/12 (2006.01); C07F 9/653 (2006.01); C07D 403/04 (2006.01); C07D 405/04 (2006.01); C07D 409/04 (2006.01); C07D 413/04 (2006.01);
U.S. Cl.
CPC ...
C07D 231/12 (2013.01); C07D 233/64 (2013.01); C07D 249/08 (2013.01); C07D 261/08 (2013.01); C07D 263/32 (2013.01); C07D 271/06 (2013.01); C07D 277/30 (2013.01); C07D 285/12 (2013.01); C07D 307/68 (2013.01); C07D 333/24 (2013.01); C07D 401/04 (2013.01); C07D 403/04 (2013.01); C07D 405/04 (2013.01); C07D 409/04 (2013.01); C07D 413/04 (2013.01); C07D 413/12 (2013.01); C07F 9/65306 (2013.01);
Abstract

The present invention relates to methods, compounds, and compositions for treating or preventing diseases associated with nonsense mutations in an mRNA by administering the compounds or compositions of the present invention. More particularly, the present invention relates to methods, compounds, and compositions for suppressing premature translation termination associated with a nonsense mutation in an mRNA.

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