The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9315453 B1

PDF
Full Text
Expired
Date of Patent:
Apr. 19, 2016

Filed:

Apr. 17, 2013
Applicant:

Kyorin Pharmaceutical Co., Ltd., Tokyo, JP;

Inventors:

Takeshi Tsubuki, Tochigi, JP;

Hiroya Sato, Tochigi, JP;

Assignee:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07C 323/20 (2006.01); C07C 319/28 (2006.01);
U.S. Cl.
CPC ...
C07C 323/20 (2013.01); C07C 319/28 (2013.01); C07B 2200/13 (2013.01);
Abstract

[Problem] For example, 4-(3-benzyloxyphenylthio)-2-chloro-1-(3-nitropropyl)benzene (compound 1) is used as an intermediate for producing a 2-amino-2-[2-[4-(3-benzyloxyphenylthio)-2-chlorophenyl]ethyl]-1,3-propanediol hydrochloride which has excellent immunosuppressive activity. This compound 1 is traditionally obtained only as an oil and thus handling and refining were difficult. [Solution] A crystal of the compound 1 is obtained. A method of crystallizing the same is also established. Furthermore, a simple refining method is also found which comprises stirring in suspension the crystal in a solvent. Since the compound 1 can be obtained as a crystal, it is easier to handle and long term storage is possible.


Find Patent Forward Citations

Tsubuki, Takeshi. (2016). 4-(3-benzyloxyphenylthio)-2-chloro-1-(3-nitropropyl)benzene crystal (U.S. Patent No. 9315453). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/9315453

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