The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Apr. 19, 2016

Filed:

Jun. 07, 2012
Applicants:

Isamu Shiina, Tokyo, JP;

Kenya Nakata, Tokyo, JP;

Keisuke Ono, Tokyo, JP;

Inventors:

Isamu Shiina, Tokyo, JP;

Kenya Nakata, Tokyo, JP;

Keisuke Ono, Tokyo, JP;

Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07C 69/76 (2006.01); C07C 67/08 (2006.01); C07D 317/68 (2006.01); C07B 57/00 (2006.01); C07D 207/337 (2006.01); C07D 209/26 (2006.01); C07D 209/46 (2006.01); C07D 209/88 (2006.01); B01J 31/02 (2006.01);
U.S. Cl.
CPC ...
C07C 67/08 (2013.01); B01J 31/0241 (2013.01); C07B 57/00 (2013.01); C07D 207/337 (2013.01); C07D 209/26 (2013.01); C07D 209/46 (2013.01); C07D 209/88 (2013.01); C07D 317/68 (2013.01); B01J 2231/49 (2013.01); C07B 2200/07 (2013.01); C07C 2101/08 (2013.01); C07C 2103/26 (2013.01);
Abstract

A method that manufacturers an optically active carboxylic acid ester at high yield and high enantioselectivity is provided. An optically active carboxylic acid ester is manufactured at high yield and high enantioselectivity by reacting a racemic carboxylic acid and a specific alcohol or phenol derivatives in a polar solvent having a dipole moment of 3.0 or higher in the presence of an acid anhydride and an asymmetric catalyst, esterifying one enantiomer of the racemic carboxylic acid at high selectivity, and increasing the amount of esterified carboxylic acid by racemizing the optically active carboxylic acid which is the other enantiomer not used in esterification.


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