The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 19, 2016
Filed:
Apr. 27, 2013
Jawaharlal Nehru Centre for Advanced Scientific Research, Bangalore, Karnataka, IN;
Universite DE Strasbourg, Strasbourg, FR;
Tapas Kumar Kundu, Karnataka, IN;
Anne-Laurence Boutillier, Strasbourg, FR;
Snehajyoti Chatterjee, Karnataka, IN;
Muthusamy Eswaramoorthy, Karnataka, IN;
Pushpak Mizar, Karnataka, IN;
Chantal Mathis, Strasbourg, FR;
Jean-Christophe Cassel, Strasbourg, FR;
Romain Neidl, Strasbourg, FR;
Mohankrishna Dalvoy Vasudevarao, Karnataka, IN;
Vedamurthy Bhusainahalli Maheshwarappa, Karnataka, IN;
JAWAHARLAL NEHRU CENTRE FOR ADVANCED SCIENTIFIC RESEARCH, Bangalore, Karnataka, IN;
UNIVERSITE DE STRASBOURG, Strasbourg, FR;
Abstract
The present invention is in relation to a composition including nanosphere and histone acetyltransferase (HAT) activator. The nanosphere is carbon nanosphere (CSP) which is intrinsically fluorescent and the HAT activator is N-(4-Chloro-3-trifluoromethyl-phenyl)-2-n-propoxy-benzamide. The N-(4-Chloro-3-trifluoromethyl-phenyl)-2-n-propoxy-benzamide is covalently conjugated with the carbon nanosphere. The present invention further relates to a process for obtaining a composition including carbon nanosphere and Histone acetyltransferase (HAT) activator [N-(4-Chloro-3-trifluoromethyl-phenyl)-2-n-propoxy-benzamide]. The composition is capable of crossing blood brain barrier and inducing histone acetylation in brain. Further, the composition is capable of increasing neurogenesis, as well as improving long-term memory formation. The composition manages pathological conditions to a subject in need thereof, such as aging-related, neurodegenerative diseases (Alzheimer's in particular), neurological disorders, depression or other kinds of diseases in which increased HAT activity, neurogenesis and/or memory improvement would benefit.