The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Apr. 19, 2016

Filed:

Jul. 11, 2011
Applicants:

Kazunori Kataoka, Tokyo, JP;

Takehiko Ishii, Tokyo, JP;

Kensuke Osada, Tokyo, JP;

Qixian Chen, Tokyo, JP;

Keiji Itaka, Tokyo, JP;

Satoshi Uchida, Tokyo, JP;

Inventors:

Kazunori Kataoka, Tokyo, JP;

Takehiko Ishii, Tokyo, JP;

Kensuke Osada, Tokyo, JP;

Qixian Chen, Tokyo, JP;

Keiji Itaka, Tokyo, JP;

Satoshi Uchida, Tokyo, JP;

Assignee:
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 48/00 (2006.01); A61K 47/18 (2006.01); C08G 81/00 (2006.01); A61K 47/34 (2006.01); A61K 47/48 (2006.01); C12N 15/87 (2006.01); A61K 9/00 (2006.01); A61K 38/00 (2006.01); C08G 63/00 (2006.01);
U.S. Cl.
CPC ...
A61K 47/34 (2013.01); A61K 47/48215 (2013.01); A61K 47/48315 (2013.01); A61K 47/48853 (2013.01); C12N 15/87 (2013.01); A61K 9/0019 (2013.01); A61K 9/0073 (2013.01); A61K 38/00 (2013.01); C08G 63/00 (2013.01);
Abstract

An excellent nucleic acid delivery composition is provided which has reduced cytotoxicity and improved nucleic acid introduction efficiency and gene expression efficiency. The composition comprises: a block copolymer having an uncharged hydrophilic polymer segment and a cationic polymer segment; a cationic polymer; and a nucleic acid, wherein the mol percentage (B/H ratio) of the cationic groups of the block copolymer to the total cationic groups of the block copolymer and the cationic polymer is between 25% and 90%.


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