The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 19, 2016
Filed:
Feb. 23, 2006
Toshihiro Sashihara, Kanagawa, JP;
Makoto Yamaguchi, Kanagawa, JP;
Yoshitaka Nakamura, Kanagawa, JP;
Shuji Ikegami, Kanagawa, JP;
Seiko Narushima, Kanagawa, JP;
Katsunori Kimura, Kanagawa, JP;
Shinya Nagafuchi, Kanagawa, JP;
Masaki Terahara, Kanagawa, JP;
Toshihiro Sashihara, Kanagawa, JP;
Makoto Yamaguchi, Kanagawa, JP;
Yoshitaka Nakamura, Kanagawa, JP;
Shuji Ikegami, Kanagawa, JP;
Seiko Narushima, Kanagawa, JP;
Katsunori Kimura, Kanagawa, JP;
Shinya Nagafuchi, Kanagawa, JP;
Masaki Terahara, Kanagawa, JP;
MEIJI CO., LTD., Tokyo, JP;
Abstract
A probioticwas discovered from lactobacilli of thegenus independently isolated from human adult feces. The probioticwas selected from other bacterial strains for: (1) being highly resistant to gastric acid/bile acid; (2) having a high promoting activity on IL-12 production from mouse derived spleen cells and a high Th1/Th2 balance-improving effect; (3) having a high ability to inhibit the production of antigen-specific IgE induced by intraperitoneally administering ovalbumin to BALB/c mice; (4) having a high ability to inhibit the production of antigen-specific IgE induced by orally administering a food antigen to C57BL/6N mice; (5) having a high Natural Killer cell-activating ability; (6) having a high IL-12 production-promoting activity on spleen cells and mesenteric lymph node cells derived from mice immunized with ovalbumin and a high Th1/Th2 balance-improving effect; and (7) having a high ability to suppress eosinophilia induced by a cedar pollen-extracted antigen. This discovery led to the completion of the present invention.