The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 12, 2016
Filed:
Feb. 14, 2014
Applicant:
Ventana Medical Systems, Inc., Tucson, AZ (US);
Inventors:
Christopher Bieniarz, Tucson, AZ (US);
Julia Ashworth-Sharpe, Tucson, AZ (US);
Casey A. Kernag, Tucson, AZ (US);
Jerome W. Kosmeder, Tucson, AZ (US);
Mark Lefever, Oro Valley, AZ (US);
Assignee:
Ventana Medical Systems, Inc., Tucson, AZ (US);
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
G01N 33/535 (2006.01); G01N 33/58 (2006.01); C07C 319/02 (2006.01); C07C 323/60 (2006.01); C07C 327/28 (2006.01); G01N 33/532 (2006.01); A61K 47/48 (2006.01); A61K 39/44 (2006.01);
U.S. Cl.
CPC ...
G01N 33/581 (2013.01); C07C 319/02 (2013.01); C07C 323/60 (2013.01); C07C 327/28 (2013.01); G01N 33/532 (2013.01); A61K 39/44 (2013.01); A61K 47/4843 (2013.01); A61K 47/48376 (2013.01); A61K 47/48384 (2013.01); G01N 33/535 (2013.01);
Abstract
A method is disclosed for making a conjugate of two molecules using a hydrazide thiol linker. In a particular working embodiment, an Fc-specific antibody-enzyme conjugate is made using the method and demonstrated to provide exceptional staining sensitivity and specificity in immunohistochemical and in situ hybridization assays.