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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9309263 B1

PDFFull Text
Date of Patent:
Apr. 12, 2016

Filed:

Jan. 28, 2014

Fused multi-cyclic sulfone compounds as inhibitors of beta-secretase and methods of use thereof

Applicant:

Amgen Inc., Thousand Oaks, CA (US);

Inventors:

Ryan White, Somerville, MA (US);

Jennifer R. Allen, Newbury Park, CA (US);

Oleg Epstein, Belmont, MA (US);

Fang-Tsao Hong, Thousand Oaks, CA (US);

Zihao Hua, Andover, MA (US);

Jason Brooks Human, Boston, MA (US);

Patricia Lopez, Woodland Hills, CA (US);

Philip R. Olivieri, Charlestown, MA (US);

Karina Romero, Arlington, MA (US);

Laurie Schenkel, Boston, MA (US);

John Stellwagen, Beverly, MA (US);

Nuria A. Tamayo, Newbury Park, CA (US);

Xiao Mei Zheng, Natick, MA (US);

Assignee:

Amgen Inc., Thousand Oaks, CA (US);

Attorneys:

Markus Bergauer

Bernard P. Friedrichsen

G. Prabhakar Reddy

Primary Examiner:

Erich A Leeser

Int. Cl.
CPC ...
C07D 417/10 (2006.01); C07D 417/14 (2006.01); C07D 513/04 (2006.01); C07D 513/14 (2006.01); C07D 417/12 (2006.01); C07D 471/04 (2006.01); C07D 487/04 (2006.01); C07D 513/10 (2006.01); C07D 513/20 (2006.01); C07D 519/00 (2006.01);
U.S. Cl.
CPC ...
C07D 513/04 (2013.01); C07D 417/12 (2013.01); C07D 471/04 (2013.01); C07D 487/04 (2013.01); C07D 513/10 (2013.01); C07D 513/14 (2013.01); C07D 513/20 (2013.01); C07D 519/00 (2013.01);
Abstract

The present invention provides a new class of compounds useful for the modulation of beta-secretase enzyme (BACE) activity. The compounds have a general Formula I: wherein variables A, A, A, R, R, R, R, X, Y, n and o of Formula I, independently, are defined herein. The invention also provides pharmaceutical compositions comprising the compounds, and corresponding uses of the compounds and compositions for treatment of disorders and/or conditions related to A-beta plaque formation and deposition, resulting from the biological activity of BACE. Such BACE mediated disorders include, for example, Alzheimer's Disease, cognitive deficits, cognitive impairments, schizophrenia and other central nervous system conditions. The invention further provides compounds of Formula II and sub-formula embodiments thereof, compounds of Formula III, intermediates and processes and methods useful for the preparation of compounds of Formulas I-III, and sub-Formulas thereof.

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