The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 12, 2016
Filed:
Dec. 02, 2014
Applicant:
Rhodes Technologies, Coventry, RI (US);
Inventors:
Joshua Robert Giguere, Sharon, MA (US);
Helge Alfred Reisch, Westerly, RI (US);
Sergio Sandoval, West Warwick, RI (US);
Jake Larry Stymiest, Foster, RI (US);
Assignee:
Rhodes Technologies, Coventry, RI (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 471/02 (2006.01); C07D 489/12 (2006.01); C07D 489/08 (2006.01); C07D 489/02 (2006.01);
U.S. Cl.
CPC ...
C07D 489/12 (2013.01); C07D 489/02 (2013.01); C07D 489/08 (2013.01);
Abstract
The present disclosure provides improved methods for N-dealkylation of tertiary amines, including methods for N-demethylation of alkaloids and opioids, in which the dealkylation reaction is carried out in a solvent comprising a tertiary alcohol. The present disclosure also provides improved processes for preparing semi-synthetic opioids that incorporate the disclosed methods for N-dealkylation of tertiary amines.