The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Apr. 12, 2016

Filed:

Oct. 05, 2012
Applicant:

Pisces Therapeutics, Llc, Rockville, MD (US);

Inventors:

James H. Wikel, Greenwood, IN (US);

Michael J. Brownstein, Rockville, MD (US);

Assignee:

Pisces Therapeutics, LLC, Rockville, MD (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 233/20 (2006.01); A61K 31/41 (2006.01); C07D 239/06 (2006.01); C07D 257/04 (2006.01); C07D 285/06 (2006.01); C07D 333/38 (2006.01); C07D 333/40 (2006.01);
U.S. Cl.
CPC ...
C07D 239/06 (2013.01); C07D 233/20 (2013.01); C07D 257/04 (2013.01); C07D 285/06 (2013.01); C07D 333/38 (2013.01); C07D 333/40 (2013.01);
Abstract

The present disclosure describes new inhibitors or antagonists of Ras useful for the treatment of conditions resulting from Ras-induced or mediated cellular processes, including cellular proliferation, differentiation, apoptosis, senescence, and survival. These cellular processes may be associated with a non-malignant or malignant disease, disorder, or pathological condition. The present disclosure also describes a method for inhibiting such Ras-induced or mediated cellular processes. The method entails administering a Ras antagonist in an amount effective to inhibit such cellular processes.


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