The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 12, 2016
Filed:
Apr. 25, 2012
Charbel Bouez, Lyons, FR;
Claudine Gleyzal, Lyons, FR;
Isabelle Orly, Irigny, FR;
Valerie Andre, Ludwigshafen, DE;
Pascal Sommer, Saint Genis Laval, FR;
Corinne Reymermier, Charly, FR;
Odile Damour, Saint Genis Laval, FR;
Eric Perrier, Les Cotes d'arey, FR;
Charbel Bouez, Lyons, FR;
Claudine Gleyzal, Lyons, FR;
Isabelle Orly, Irigny, FR;
Valerie Andre, Ludwigshafen, DE;
Pascal Sommer, Saint Genis Laval, FR;
Corinne Reymermier, Charly, FR;
Odile Damour, Saint Genis Laval, FR;
Eric Perrier, Les Cotes d'arey, FR;
BASF Beauty Care Solutions France S.A.S., Lyons, FR;
Centre National De La Recherche Scientifique, Paris, FR;
Université Claude Bernard Lyon 1, Villeurbanne, FR;
Abstract
The disclosed substance restores normal co-expression and interaction between the LOX and NRAGE proteins. Particularly, an effective amount of the substance that modulates the expression and/or activity of LOX of SEQ ID NO: 1 and/or that modulates the expression and/or activity of NRAGE of SEQ ID NO: 2, may be used for the manufacture of a composition for modulating the interaction between the LOX and NRAGE proteins to regulate the balance between the cellular phenomena of proliferation, differentiation and apoptosis, particularly in cases where the balance between these phenomena is disturbed, and especially in cases where the interaction between LOX and NRAGE is absent or altered. The invention makes it possible especially to treat and/or prevent skin ageing, lichen planus, graft-versus-host reaction (GVH), eczema, psoriasis and a cancer, particularly an epithelial cancer and more particularly a cutaneous epithelial cancer of basocellular or spinocellular type.