The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 05, 2016
Filed:
Nov. 17, 2014
Applicant:
The University of Tokyo, Tokyo, JP;
Inventors:
Kazunori Kataoka, Tokyo, JP;
Yan Lee, Tokyo, JP;
Nobuhiro Nishiyama, Tokyo, JP;
Kanjiro Miyata, Tokyo, JP;
Makoto Oba, Tokyo, JP;
Shigehiro Hiki, Tokyo, JP;
Mai Sanjo, Tokyo, JP;
HyunJin Kim, Tokyo, JP;
Assignee:
THE UNIVERSITY OF TOKYO, Tokyo, JP;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C08G 69/48 (2006.01); A61K 31/7084 (2006.01); A61K 31/785 (2006.01); A61K 48/00 (2006.01); C08G 69/10 (2006.01); C08G 69/40 (2006.01); C12N 15/11 (2006.01); C12N 15/88 (2006.01);
U.S. Cl.
CPC ...
C08G 69/48 (2013.01); A61K 31/7084 (2013.01); A61K 31/785 (2013.01); A61K 48/0041 (2013.01); C08G 69/10 (2013.01); C08G 69/40 (2013.01); C12N 15/111 (2013.01); C12N 15/88 (2013.01); C12N 2310/14 (2013.01); C12N 2320/32 (2013.01);
Abstract
Disclosed is a polymer composite (polyplex) that contains nucleic acid, a cationic polymer, and an anionic polymer. The anionic polymer covers the surface of the composite comprising the cationic polymer and nucleic acid, has a negative charge at neutral pH, and can change so as to have a positive charge at mildly acidic pH.