The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 05, 2016
Filed:
Aug. 14, 2013
Applicant:
Amgen Inc., Thousand Oaks, CA (US);
Inventors:
Kenneth Allan Brasel, Sattle, WA (US);
James F Smothers, Quincy, MA (US);
Douglas Pat Cerretti, Shoreline, WA (US);
Assignee:
AMGEN INC., Thousand Oaks, CA (US);
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 39/00 (2006.01); A61K 39/395 (2006.01); C12N 5/16 (2006.01); C07K 16/00 (2006.01); C12P 21/08 (2006.01); C07K 16/18 (2006.01); C07K 14/715 (2006.01); C07K 16/28 (2006.01);
U.S. Cl.
CPC ...
C07K 16/18 (2013.01); C07K 14/7153 (2013.01); C07K 16/2866 (2013.01); A61K 2039/505 (2013.01); C07K 2316/96 (2013.01); C07K 2317/21 (2013.01); C07K 2317/56 (2013.01); C07K 2317/565 (2013.01); C07K 2317/567 (2013.01); C07K 2317/73 (2013.01); C07K 2317/76 (2013.01); C07K 2317/92 (2013.01);
Abstract
Antigen binding proteins that bind to human c-fms protein are provided. Nucleic acids encoding the antigen binding protein, vectors, and cells encoding the same are also provided. The antigen binding proteins can inhibit binding of c-fms to CSF-1, reduce monocyte migration into tumors, and reduce the accumulation of tumor-associated macrophages.