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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9303061 B1

PDFFull Text
Date of Patent:
Apr. 05, 2016

Filed:

Jul. 09, 2012

Spiro compounds as hepatitis c virus inhibitors

Applicants:

Jiancun Zhang, San Mateo, CA (US);

Yingjun Zhang, Dongguan, CN;

Hongming Xie, Dongguan, CN;

Qingyun Ren, Dongguan, CN;

Huichao Luo, Dongguan, CN;

Tianzhu Yu, Dongguan, CN;

Yumei Tan, Dongguan, CN;

Inventors:

Jiancun Zhang, San Mateo, CA (US);

Yingjun Zhang, Dongguan, CN;

Hongming Xie, Dongguan, CN;

Qingyun Ren, Dongguan, CN;

Huichao Luo, Dongguan, CN;

Tianzhu Yu, Dongguan, CN;

Yumei Tan, Dongguan, CN;

Assignee:

Sunshine Luke Pharma Co., Ltd., Dongguan, Guangdong, CN;

Attorneys:

Kam W. Law

Squire Patton Boggs (US) LLP

Primary Examiner:

Alicia L Otton

Assistant Examiner:

Jeanmarie Calvillo

Int. Cl.
CPC ...
A61K 39/00 (2006.01); C07D 235/02 (2006.01); A61K 31/5377 (2006.01); A61K 31/438 (2006.01); A61K 38/00 (2006.01); C07D 277/00 (2006.01); C07D 491/00 (2006.01); A61K 38/21 (2006.01); C07K 5/062 (2006.01); C07D 401/14 (2006.01); C07D 405/14 (2006.01); C07D 403/14 (2006.01); C07D 409/14 (2006.01); C07D 471/04 (2006.01); A61K 45/06 (2006.01); A61K 38/05 (2006.01);
U.S. Cl.
CPC ...
C07K 5/06052 (2013.01); A61K 38/05 (2013.01); A61K 45/06 (2013.01); C07D 401/14 (2013.01); C07D 403/14 (2013.01); C07D 405/14 (2013.01); C07D 409/14 (2013.01); C07D 471/04 (2013.01);
Abstract

Disclosed are spiro compounds of formula (I), or stereomers, geometric isomers, tautomers, nitrogen oxides, hydrates, solvates, metabolites, pharmaceutically acceptable salts or prodrugs thereof. The compounds can be used to treat hepatitis C virus (HCV) infection or hepatitis C disease. Furthermore disclosed are pharmaceutical compositions containing the compounds and the method of using the compounds or pharmaceutical compositions in the treatment of HCV infection or hepatitis C disease.

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