The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 05, 2016
Filed:
Jul. 24, 2015
Applicant:
Chimerix, Inc., Durham, NC (US);
Inventors:
Roy W. Ware, Raleigh, NC (US);
Merrick R. Almond, Apex, NC (US);
Bernhard M. Lampert, Rougemont, NC (US);
Assignee:
Chimerix Inc., Durham, NC (US);
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/675 (2006.01); C07F 9/40 (2006.01); C07F 9/38 (2006.01); C07F 9/6512 (2006.01); C07F 9/6571 (2006.01);
U.S. Cl.
CPC ...
C07F 9/4021 (2013.01); A61K 31/675 (2013.01); C07F 9/3808 (2013.01); C07F 9/4006 (2013.01); C07F 9/65121 (2013.01); C07F 9/657181 (2013.01);
Abstract
The disclosure describes methods of synthesis of phosphonate ester derivatives. Preferred methods according to the disclosure allow for large-scale preparation of phosphonate ester compounds having high purity. In some embodiments, preferred methods according to the disclosure also allow for the preparation of phosphonate ester derivatives without the use of chromatographic purification methods and in better yield than previously used methods for preparing such compounds. Also disclosed are morphic forms of phosphonate ester derivatives.