The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Apr. 05, 2016

Filed:

Jan. 16, 2013
Applicants:

The Rockefeller University, New York, NY (US);

The United States of America, As Represented BY the Secretary, Department of Health and Human Services, Washington, DC (US);

Mount Sinai School of Medicine, Office of Technology and Business Development, New York, NY (US);

Inventors:

Barry S. Coller, New York, NY (US);

Craig Thomas, Rockville, MD (US);

Marta Filizola, New York, NY (US);

Joshua McCoy, Portland, ME (US);

Wenwei Huang, Rockville, MD (US);

Min Shen, Boyds, MD (US);

Jian-Kang Jiang, Columbia, MD (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A01N 43/90 (2006.01); A61K 31/519 (2006.01); C07D 471/00 (2006.01); C07D 487/00 (2006.01); C07D 491/00 (2006.01); C07D 513/04 (2006.01); A61K 45/06 (2006.01); A61K 31/436 (2006.01); A61K 31/337 (2006.01); A61K 31/4353 (2006.01); A61K 31/727 (2006.01); A61L 31/02 (2006.01); A61L 31/10 (2006.01); A61L 31/16 (2006.01);
U.S. Cl.
CPC ...
C07D 513/04 (2013.01); A61K 31/337 (2013.01); A61K 31/436 (2013.01); A61K 31/4353 (2013.01); A61K 31/519 (2013.01); A61K 31/727 (2013.01); A61K 45/06 (2013.01); A61L 31/022 (2013.01); A61L 31/10 (2013.01); A61L 31/16 (2013.01); A61L 2300/416 (2013.01); A61L 2300/42 (2013.01); A61L 2300/45 (2013.01);
Abstract

The present invention relates to compounds and compositions of Formula P useful for inhibiting and/or reducing platelet deposition, adhesion and/or aggregation. The definitions of variables A, B, R, R, R, R, R', R, R′, R, R, R′, R, and R′ are provided in the disclosure. The present invention further relates to methods for the treatment or prophylaxis of thrombotic disorders, including stroke, myocardial infarction, unstable angina, peripheral vascular disease, abrupt closure following angioplasty or stent placement and thrombosis as a result of vascular surgery.


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