The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 05, 2016
Filed:
Mar. 27, 2013
Applicant:
The Regents of the University of California, Oakland, CA (US);
Inventors:
Marc Anderson, San Francisco, CA (US);
Alan S. Verkman, San Francisco, CA (US);
Assignee:
The Regents of the University of California, Oakland, CA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/519 (2006.01); C07D 495/22 (2006.01); A61P 7/10 (2006.01); A61P 9/12 (2006.01); A61P 9/04 (2006.01); A61P 13/12 (2006.01); A61P 13/02 (2006.01);
U.S. Cl.
CPC ...
C07D 495/22 (2013.01); A61K 31/519 (2013.01);
Abstract
Provided herein are small molecule triazolothienopyrimidine compounds that inhibit urea transport activity of solute transporters, particularly the UT-B transporter. The compounds described herein are useful for increasing solute clearance in states of fluid overload and for treating refractory edema associated with cardiovascular, renal, and metabolic diseases, disorders, and conditions.