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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9302989 B1

PDFFull Text
Date of Patent:
Apr. 05, 2016

Filed:

Nov. 11, 2011

Nampt and rock inhibitors

Applicants:

Michael L. Curtin, Pleasant Prairie, WI (US);

Bryan K. Sorensen, Antioch, IL (US);

Howard R. Heyman, Deerfield, IL (US);

Richard F. Clark, Gurnee, IL (US);

Kevin R. Woller, Antioch, IL (US);

Omar J. Shah, Issaquah, WA (US);

Michael Michaelides, Libertyville, IL (US);

Chris Tse, Libertyville, IL (US);

Anil Vasudevan, Union Grove, WI (US);

Helmut Mack, Ludwigshafen, DE;

Todd M. Hansen, Grayslake, IL (US);

Ramzi Sweis, Lake Bluff, IL (US);

Marina A. Pliushchev, Vernon Hills, IL (US);

Inventors:

Michael L. Curtin, Pleasant Prairie, WI (US);

Bryan K. Sorensen, Antioch, IL (US);

Howard R. Heyman, Deerfield, IL (US);

Richard F. Clark, Gurnee, IL (US);

Kevin R. Woller, Antioch, IL (US);

Omar J. Shah, Issaquah, WA (US);

Michael Michaelides, Libertyville, IL (US);

Chris Tse, Libertyville, IL (US);

Anil Vasudevan, Union Grove, WI (US);

Helmut Mack, Ludwigshafen, DE;

Todd M. Hansen, Grayslake, IL (US);

Ramzi Sweis, Lake Bluff, IL (US);

Marina A. Pliushchev, Vernon Hills, IL (US);

Assignee:

AbbVie Inc., North Chicago, IL (US);

Attorney:

Glen J. Gesicki

Primary Examiner:

Jeffrey H Murray

Int. Cl.
CPC ...
A01N 43/38 (2006.01); A61K 31/40 (2006.01); C07D 209/44 (2006.01); C07D 401/12 (2006.01); C07D 401/14 (2006.01); C07D 403/10 (2006.01); C07D 407/12 (2006.01); C07D 407/14 (2006.01); C07D 413/12 (2006.01); C07D 417/12 (2006.01); C07D 471/04 (2006.01); C07D 491/048 (2006.01); C07D 495/04 (2006.01); C07D 403/12 (2006.01); C07D 403/14 (2006.01); C07D 405/12 (2006.01);
U.S. Cl.
CPC ...
C07D 209/44 (2013.01); C07D 401/12 (2013.01); C07D 401/14 (2013.01); C07D 403/10 (2013.01); C07D 403/12 (2013.01); C07D 403/14 (2013.01); C07D 405/12 (2013.01); C07D 407/12 (2013.01); C07D 407/14 (2013.01); C07D 413/12 (2013.01); C07D 417/12 (2013.01); C07D 471/04 (2013.01); C07D 491/048 (2013.01); C07D 495/04 (2013.01);
Abstract

Disclosed are 1,3-dihydro-2H-isoindole compounds which inhibit the activity of NAMPT, compositions containing the compounds and methods of using the compounds to treat diseases during which NAMPT is expressed, e.g., cancer, metabolic disorders, and inflammatory disorders. Disclosed are 1,3-dihydro-2H-isoindole compounds which inhibit the activity of ROCK, compositions containing the compounds and methods of using the compounds to treat diseases during which ROCK is expressed, e.g., cancer, cardiovascular disorders, and inflammatory disorders.

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