The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Apr. 05, 2016

Filed:

May. 31, 2011
Applicants:

Hideki Hayashi, Chiba, JP;

Masanori Fujinami, Chiba, JP;

Taro Toyota, Chiba, JP;

Yutaka Tamura, Chiba, JP;

Akira Aoki, Kyoto, JP;

Yutaka Muraki, Kyoto, JP;

Kazuki Onoue, Kyoto, JP;

Inventors:

Hideki Hayashi, Chiba, JP;

Masanori Fujinami, Chiba, JP;

Taro Toyota, Chiba, JP;

Yutaka Tamura, Chiba, JP;

Akira Aoki, Kyoto, JP;

Yutaka Muraki, Kyoto, JP;

Kazuki Onoue, Kyoto, JP;

Assignee:
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 49/00 (2006.01); C07D 209/60 (2006.01); C09B 23/08 (2006.01);
U.S. Cl.
CPC ...
A61K 49/0084 (2013.01); A61K 49/0032 (2013.01); A61K 49/0034 (2013.01); C07D 209/60 (2013.01); C09B 23/086 (2013.01);
Abstract

Disclosed is a near-infrared fluorescent imaging agent comprising an indocyanine-based fluorescent dye and a liposome. The near-infrared fluorescent imaging agent of the present invention demonstrates high fluorescence intensity and a long anchoring time in sentinel lymph nodes, thereby making it useful for detecting sentinel lymph nodes in sentinel lymph node navigation surgery. Also disclosed is an indocyanine green derivative that is particularly suitable for use in the near-infrared fluorescent imaging agent of the present invention.


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