The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 05, 2016
Filed:
Aug. 29, 2012
Michael John Gait, Cambridge, GB;
Andrey Alexandrovich Arzumanov, Cambridge, GB;
Amer F. Saleh, Cambridge, GB;
Matthew J. A. Wood, Oxford, GB;
Corinne Betts, Oxford, GB;
Taeyoung Koo, Oxford, GB;
Michael John Gait, Cambridge, GB;
Andrey Alexandrovich Arzumanov, Cambridge, GB;
Amer F. Saleh, Cambridge, GB;
Matthew J. A. Wood, Oxford, GB;
Corinne Betts, Oxford, GB;
Taeyoung Koo, Oxford, GB;
Medical Research Council, Swindon, GB;
Abstract
The present invention discloses cell penetrating peptides (CPP or membrane translocating peptide) and their conjugates with cargo molecules. The peptides are useful as drug delivery systems, particularly as delivery vehicles for nucleotide-based therapeutics, such as polynucleotides, oligonucleotides and peptide nucleic acids. A CPPs of the invention provides a balance between good cell entry efficiency and low toxicity and comprises three contiguous domains: the central one being hydrophobic and the flanking ones consisting of arginine and aminohexanoic acid or beta-alanine residues. The hydrophobic domain contains a sequence selected from YQFLI, YRFLI, IQFLI and IRFLI.