The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 05, 2016
Filed:
Jan. 04, 2015
Applicant:
Yeda Research and Development Co. Ltd., Rehovot, IL;
Inventors:
Assignee:
Yeda Research and Development Co. Ltd., Rehovot, IL;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07H 21/02 (2006.01); C07H 21/04 (2006.01); A61K 48/00 (2006.01); A61K 35/39 (2015.01); C12N 5/071 (2010.01); C12N 15/113 (2010.01); A61K 31/713 (2006.01); A61K 38/46 (2006.01); A01K 67/027 (2006.01);
U.S. Cl.
CPC ...
A61K 35/39 (2013.01); A01K 67/0276 (2013.01); A61K 31/713 (2013.01); A61K 38/465 (2013.01); C12N 5/0676 (2013.01); C12N 15/113 (2013.01); A01K 2217/15 (2013.01); A01K 2217/203 (2013.01); A01K 2217/206 (2013.01); A01K 2227/105 (2013.01); A01K 2267/03 (2013.01); A01K 2267/0362 (2013.01); A01K 2267/0393 (2013.01); A61K 48/00 (2013.01); C12N 2310/141 (2013.01); C12N 2330/50 (2013.01); C12N 2501/65 (2013.01); C12N 2510/00 (2013.01);
Abstract
A method of increasing insulin content in a pancreatic beta cell is disclosed. The method comprising expressing in the pancreatic beta cell an exogenous polynucleotide encoding at least one microRNA or a precursor thereof, wherein the microRNA is selected from the group consisting of miR-15, miR-16, miR-24, miR-26, miR-27, miR-29, miR-30, miR-129, miR-141, miR-148, miR-182, miR-200, miR-376 and Let-7, thereby increasing the insulin content in the pancreatic beta cell.