The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 05, 2016
Filed:
Jun. 20, 2012
Applicants:
Lennart Svensson, Solna, SE;
Hans Sidén, Sollentuna, SE;
Inventors:
Lennart Svensson, Solna, SE;
Hans Sidén, Sollentuna, SE;
Assignee:
SWEDISH ORPHAN BIOVITRUM INTERNATIONAL AB, Stockholm, SE;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/122 (2006.01); A61K 47/12 (2006.01); A61K 47/10 (2006.01); A61K 47/26 (2006.01); A61K 9/10 (2006.01); A61K 47/38 (2006.01);
U.S. Cl.
CPC ...
A61K 31/122 (2013.01); A61K 9/10 (2013.01); A61K 47/10 (2013.01); A61K 47/12 (2013.01); A61K 47/26 (2013.01); A61K 47/38 (2013.01);
Abstract
The invention concerns a liquid pharmaceutical formulation suitable for oral administration, comprising a suspension of an effective amount of micronized 2-(2-nitro-4-trifluoromethylbenzoyl)-1,3-cyclohexanedione (nitisinone); and citric acid buffer having a pH in the range of 2.5 to 3.5. The formulation is useful in the treatment of disorders and diseases in which inhibition of 4-hydroxyphenylpyruvate dioxygenase (HPPD) is desirable, e.g. in hereditary tyrosinaemia type I.